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Deep tech diagnostics for the AI-driven era
⭐ WELCOME TO THE FUTURE

Guanine: Healthcare Reimagined

A new class of diagnostics for the intelligence-driven era of healthcare.

Guanine is building a software-defined electrochemical sensing platform for multi-omic diagnostics and real-time phenotyping.

Our technology transforms electrochemistry into a programmable sensing layer, where chemistry, waveforms, and signal encoding are defined in software—not optics or biology-specific hardware. This enables a single low-cost engine to adapt across biology, applications, and workflows.

A single platform measures hundreds of biomarkers, identifies pathogens, and reads drug response in real time—without optics, PCR, or complex instrumentation.

Detect nucleic acids, proteins, metabolites, cells, and redox-active materials from a single sample. Quantify hundreds of analytes. Perform culture-free phenotyping. Deliver time-aligned sepsis insight within a 90–120 minute window.

A new diagnostic infrastructure for hospitals and OEM innovators.
⭐ THE HEALTHCARE PROBLEM

Diagnostics Has Reached Its Limits

Healthcare depends on aging diagnostic technologies—PCR, immunoassays, sequencing, LC/MS, flow cytometry, and culture—that are fragmented, slow, expensive, and impossible to unify.

  • Sepsis outcomes remain poor due to slow, incomplete data
  • Phenotyping still depends on growth-based methods from the 1960s
  • Optical platforms are constrained by spectral crowding and cost
  • Hospitals are under economic pressure to decentralize and accelerate testing
  • OEMs lack a scalable, flexible sensing layer to build the next generation of assays
The result: delayed decisions, higher costs, and preventable patient harm.
⭐ GUANINE’S BREAKTHROUGH SOLUTION

A Universal Electrochemical Platform for Unlimited Biology

Guanine developed a reversible quadruplex-tag detection architecture that transforms diagnostics into a single unified sensing layer.

  • Measure DNA, RNA, proteins, metabolites, whole cells, and redox chemistry
  • 500-analyte multiplexing through composite encoding
  • Real-time phenotyping (minutes to signal; ~90-minute classification)
  • 20-minute inflammation and sepsis rule-in/rule-out
  • Broad pathogen and resistance gene detection
  • OEM-ready integration across pharma, oncology, wellness, precision health, and AI
  • Lowest-cost architecture for high-plex testing—no optics, pumps, or thermal cycling
Guanine replaces fragmented diagnostic stacks with a single, programmable sensing layer. “One Platform. Unlimited Biology.”
⭐ DEEP TECH DX

Electrochemical Deep Tech for the Next Generation of Diagnostics

Guanine unifies reversible quadruplex tags, multi-domain waveform control, magnetic concentration, and composite multiplex encoding into a single electrochemical engine—built for multi-omic, AI-ready diagnostics.

One electrochemical engine. Multiple diagnostic modes.
Culture-free phenotyping

Culture-Free Phenotyping

Real-time electrochemical kinetics across multiple antibiotics on a single cartridge.

Multi-omic in one run

Multi-Omic in One Run

Nucleic acids, proteins, metabolites, cells, and redox-active chemistry from the same sample.

Platform for OEM innovators

Platform for OEM Innovators

A universal electrochemical engine designed as the sensing layer for future diagnostic systems.

⭐ WHY NOW

The Diagnostic Landscape Has Shifted—Permanently

Clinical Drivers
  • Sepsis and AMR require rapid, actionable data
  • Drug susceptibility must move beyond culture
  • Clinicians need integrated host–pathogen insight
Economic Drivers
  • Hospitals face severe cost and staffing pressures
  • Diagnostics must move closer to the patient
OEM & Technology Drivers
  • Optical platforms are hitting hard multiplexing limits
  • AI requires high-plex, quantitative multi-omic data
  • Precision health depends on rich biomarker signatures at low cost
Guanine is the first diagnostics platform designed for this reality.
Explore how Guanine is transforming sepsis care, OEM diagnostics, and precision health.
Explore Guanine's technology See our sepsis solutions View OEM platforms