Electrochemistry has long promised fast, low-cost diagnostics, but traditional approaches were fundamentally limited. Conventional electrochemical sensors could detect only native redox molecules or simple redox tags, leaving most clinically relevant biology—proteins, nucleic acids, metabolites, and cells—out of reach. Early attempts to extend capability through DNA oxidation failed because the DNA itself decomposes, producing unstable signals and making reliable multiplexing impossible.
Guanine overcomes this foundational limitation with reversible quadruplex redox tags that remain chemically intact through repeated measurements and can be loaded by the thousands to millions onto a single magnetic particle. This transforms electrochemistry from a niche sensing method into a general-purpose detection engine, compatible with virtually any ligand type and capable of measuring proteins, nucleic acids, metabolites, redox species, and even whole cells through a single, low-cost interface.
This universal chemistry forms the base layer of Guanine’s software-defined electrochemical architecture. Rather than relying on optics, channels, or modality-specific hardware, Guanine encodes target identity, multiplexing depth, and panel composition algorithmically—decoupling diagnostic scale from physical instrumentation.
On top of this sensing foundation, Guanine integrates two core signal-processing breakthroughs:
Together, these systems allow Guanine to separate, identify, and quantify hundreds of signals that would otherwise overlap—turning electrochemistry into a high-plex, multi-omic sensing platform whose capabilities are defined in software rather than constrained by hardware.
Guanine’s universal chemistry and signal-engineering architecture: magnetic particles loaded with reversible tags create strong amplified signals; CME and MDWC decode and extract multi-omic information with extreme sensitivity, precision, and multiplexing.
Without exposing proprietary algorithms or waveform structures, these innovations turn a simple, inexpensive electrochemical reader into a multi-omic, extreme-plex diagnostic engine. The result is a platform capable of addressing use cases traditionally served by multiple legacy technologies (PCR, immunoassay, metabolomics) with faster turnaround times, lower cost, and seamless adaptability across clinical and OEM applications including sepsis, oncology, neurology, cardiology, infectious disease, and precision health.
Six core technology pillars power Guanine’s competitive advantage: a unified architecture that integrates breakthrough chemistry with advanced signal engineering to deliver rapid, culture-free, multi-omic analysis at multiplexing and sensitivity levels unattainable by traditional platforms. Each pillar contributes independently to performance, while together forming a tightly integrated diagnostic engine.
Stackable, reversible redox tags generate clean, distinct peaks that remain stable through repeated interrogation.
Millions of tags per analyte provide inherent signal amplification and universal compatibility across biomarker classes.
A multi-domain encoding framework that uniquely resolves many analytes on the same electrode by combining distinct tag chemistries with programmable electrode- and waveform-domain addressing.
A programmable waveform engine that adapts dynamically to target behavior and sample conditions, maximizing extraction of meaningful signal.
Magnetic fields accelerate binding kinetics and enhance sensitivity without pumps or complex microfluidics.
A single engine capable of measuring nucleic acids, proteins, metabolites, cells, and redox species on one cartridge.
Guanine’s IP estate protects every layer of the platform—from reversible redox chemistry and universal sandwich architectures to the multiplexing and waveform engines that enable extreme-plex, real-time measurement.
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Selected peer-reviewed and conference publications demonstrating core technology performance.
